July 2, 2012

New Research Shows Risk Factors for REM Sleep Behavior Disorder

By Anuj Chandra, M.D., D.ABSM

A new research study has shown a connection between smoking, head injury and pesticide use and a rare sleep disorder called REM Sleep Behavior Disorder, in which people kick or punch during sleep.

Normally, when we go into rapid eye movement (REM) sleep and start dreaming, we lose muscle tone and remain literally paralyzed for as long as we are dreaming. People with REM Sleep Behavior Disorder do not lose the ability to move, however. Instead, their dreams actually cause them to move. In mild cases, they may kick or punch during sleep. In more severe cases, they may get out of bed and act out their dreams. Whether the condition is mild or severe, people with this disorder may be a danger to themselves and to their bed partner because their movements can sometimes become violent.

Until this study, very little was known about risk factors for the disorder, except that it is more common in men and older people. It occurs in 0.5 percent of adults. About 45 percent of cases are linked to withdrawal from alcohol, sedatives or antidepressants, with the rest of cases having unknown cause.

The study, from McGill University in Canada, shows that people with REM Sleep Behavior Disorder were:
  • 43 percent more likely to be smokers,
  • 59 percent more likely to have had a previous head injury with loss of consciousness,
  • 67 percent more likely to have worked as farmers, and
  • more than twice as likely to have been exposed to pesticides through work.
What this tells us is that people with these risk factors need to be monitored carefully for signs of REM Sleep Behavior Disorder.

Unfortunately, the study did not provide any new insights into treatment, which currently involves giving a muscle relaxer and making changes to the sleeping environment to reduce the risk of injury.

This research was prompted because more than 50 percent of people with REM Sleep Behavior Disorder eventually develop Parkinson's disease or other degenerative neurological disease. But the connection with Parkinson's was inconsistent, with some risk factors shared between the two and other factors not connected.